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Injectable Protein to Prevent Obesity and Diabetes

Obesity and diabetes is a condition that can cause various complications to the body. But now obesity and diabetes can be prevented by injecting the protein.

York University researchers have identified a new protein that plays an important role in maintaining appetite and blood sugar levels. Protein called nesfatin-1 is widely present in the brain.

In this study known to rats given injections of nesfatin-1 protein to consume less food, so many uses of fat in the body and become more active. In addition, these proteins also stimulate insulin secretion from rat pancreatic cells.

“In addition they are more active, we found that they increased fatty acid oxidation, which means removing more fat and lose weight,” said Suraj Unniappan, professor in the Department of Biology, Faculty of Science & Engineering York University, quoted by ScienceDaily.

Nesfatin-1 protein itself has been discovered by a research team from Japan in 2006 which is used to regulate appetite and body fat production. While the focus of this study to identify the biological effects of hormone influence appetite in the brain that regulates metabolism.

The injected proteins known to interact with other proteins present in endocrine tissues to maintain stable blood glucose levels and body weight. But until now researchers did not yet know how the mechanism.

“Treatment with hormones to suppress body weight and blood sugar is very promising. We will explore the therapeutic potential of nesfatin-1 in metabolic disease with debilitating complications,” he said.

The results of studies conducted

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Hormone Therapy for Patients with Heart Disease is Dangerous

In patients with prostate cancer, hormone therapy can increase the success of the main therapeutic radiotherapy. But if the patient’s prostate cancer had a history of heart disease, hormone therapy is dangerous because it can increase the risk of death.

It was concluded in a study published online in the International Journal of Radiation Oncology Biology Physics official scientific journal of ASTRO. According to the study, patients with prostate cancer who have heart disease, including those most at risk from hormone therapy.

Research conducted from 1991 to 2006 were studied 14 594 men with prostate cancer treated with brachytherapy using radiation therapy. Of these, 1378 or about 9.4 percent had a history of heart failure.

Among people with heart conditions, 22.6 percent received additional external radiation beam therapy and 42.9 percent getting androgen deprivation therapy for four months. Androgen deprivation therapy is done to reduce levels of the hormone testosterone in the body that can slow cancer growth.

In the group of prostate cancer men with a history of heart disease, the addition of hormone therapy causes a significant increase in the level of risk of death. Prostate cancer in men who already have heart disease, researchers found that within 5 years of 31.8 percent of men who received hormone therapy died. While prostate cancer in men who did not receive hormone therapy, only 19.5 percent died.

“We found that in men with localized prostate cancer and had a history of heart disease, treatment with radiation plus hormone therapy is associated with higher mortality compared with treatment with radiation alone,” said Paul L Nguyen, MD, lead author of the study and a radiation oncologist at Dana-Farber/Brigham and Women’s Cancer Center in Boston as quoted by ScienceDaily.

Further research is needed to understand the mechanism of this effect. For a while, the researchers suggested that patients with prostate cancer who have a history of heart disease consult with their doctor first if you want to use hormone therapy.

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Less Active at Work, Americans Have Packed on Pounds

Looking beyond poor eating habits and a couch-potato lifestyle, a group of researchers has found a new culprit in the obesity epidemic: the American workplace.

A sweeping review of shifts in the labor force since 1960 suggests that a sizable portion of the national weight gain can be explained by declining physical activity during the workday. Jobs requiring moderate physical activity, which accounted for 50 percent of the labor market in 1960, have plummeted to just 20 percent.

The remaining 80 percent of jobs, the researchers report, are sedentary or require only light activity. The shift translates to an average decline of about 120 to 140 calories a day in physical activity, closely matching the nation’s steady weight gain over the past five decades, according to the report, published Wednesday in the journal PLoS One.

Today, an estimated one in three Americans are obese. Researchers caution that workplace physical activity most likely accounts for only one piece of the obesity puzzle, and that diet, lifestyle and genetics all play an important role.

But the new emphasis on declining workplace activity also represents a major shift in thinking, and it suggests that health care professionals and others on the front lines against obesity, who for years have focused primarily on eating habits and physical activity at home and during leisure time, have missed a key contributor to America’s weight problem. The findings also put pressure on employers to step up workplace heath initiatives and pay more attention to physical activity at work.

“If we’re going to try to get to the root of what’s causing the obesity epidemic, work-related physical activity needs to be in the discussion,” said Dr. Timothy S. Church, a noted exercise researcher at the Pennington Biomedical Research Center in Baton Rouge, La., and the study’s lead author. “There are a lot of people who say it’s all about food. But the work environment has changed so much we have to rethink how we’re going to attack this problem.”

The report shows that in 1960, one out of two Americans had a job that was physically active. Now it is estimated that only one in five Americans achieves a relatively high level of physical activity at work. Dr. Church notes that because the research doesn’t factor in technological changes, like increasing reliance on the Internet and e-mail, many people in service and desk jobs that have always involved only light activity are now moving less than ever, meaning the findings probably understate how much physical activity has been lost during work hours.

While it has long been known that Americans are more sedentary at work compared with the farming and manufacturing workers of 50 years ago, the new study is believed to be the first in which anyone has estimated how much daily caloric expenditure has been lost in the workplace.

“It’s a light bulb, ‘aha’ moment,” said Barbara E. Ainsworth, the president-elect of the American College of Sports Medicine and an exercise researcher at Arizona State University. “I think occupational activity is part of that missing puzzle that is so difficult to measure, and is probably contributing to the inactivity and creeping obesity that we’re seeing over time.”

For years, the role that physical activity has played in the obesity problem has been uncertain. Numerous studies suggest there has been little change in the average amount of leisure-time physical activity, posing a conundrum for researchers trying to explain the country’s steady weight gain. As a result, much of the focus has been on the rise of fast-food and soft drink consumption.

Other studies have suggested that changing commuting habits, declining reliance on public transportation and even increased time in front of the television have played a role in the fattening of America. But none of those issues can fully explain the complex changes in nationwide weight-gain patterns.

Some earlier research has hinted at the fact that workplace physical activity is associated with weight and health. One seminal set of studies of London bus drivers and conductors showed that the sedentary bus drivers had higher rates of heart disease than the ticket-takers, who moved around during the workday.

Dr. Church said that during a talk on the country’s obesity patterns, he was struck by the fact that Mississippi and Wisconsin both have high rates of obesity, despite having little in common in terms of demographics, education or even weather. It occurred to him that both states have waning agricultural economies, prompting him to begin exploring the link between changes in the labor force and declines in workplace physical activity.

He quickly discovered that a decline in farming jobs alone could not explain increasing obesity around the country, and began exploring job shifts over several decades. Using computer models, Dr. Church and colleagues assigned metabolic equivalent values to various job categories and then calculated changes in caloric expenditure at work from 1960 to 2008.

“You see the manufacturing jobs plummet and realize that’s a lot of physical activity,” said Dr. Church. “It’s very obvious that the jobs that required a lot of physical activity have gone away.”

Ross C. Brownson, an epidemiologist at Washington University in St. Louis, said that both health professionals and the public needed to broaden the traditional definition of physical activity as something that occurs during planned exercise, like running or working out at the gym.

“We need to think about physical activity as a more robust concept than just recreational physical activity,” said Dr. Brownson, whose 2005 report on declining physical activity in the workplace is cited in the PLoS One report. “In many ways we’ve engineered physical activity out of our lives, so we’ve got to find ways to put it back into our lives, like taking walks during breaks or having opportunities for activity that are more routine to our daily lives, not just going to the health club.”

Researchers said it is unlikely that the lost physical activity can ever be fully restored to the workplace, but employers do have the power to increase the physical activity of their employees by offering subsidized gym memberships or incentives to use public transit. Some companies have set up standing workstations, and marketers now offer treadmill-style desks. Employers can also redesign offices to encourage walking, by placing printers away from desks and encouraging face-to-face communication, rather than e-mail.

“The activity we get at work has to be intentional,” said Dr. Ainsworth. “When people think of obesity they always think of food first, and that’s one side of it, but it’s high time to look at the amount of time we spend inactive at work.”

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Too Much to Drink? Try Yoga

If the holiday festivities have left you feeling like your body needs a good wringing out, a trip to the yoga studio — or your own yoga mat at home — may be just what the doctor ordered. Whether you choose a gentle, restorative approach or a more vigorous one like Power Yoga, designed for the exceptionally fit, yoga can help to revive a fuzzy mind or aching body and bring relief from that bane of New Year’s Day: the hangover.

Though there is no evidence to support claims that yoga will eliminate alcohol’s toxic effects, “we do feel that yoga reduces stress and has health benefits,” said Dr. Debbie L. Cohen, a kidney specialist at the University of Pennsylvania who is studying yoga as an alternative to medication to lower high blood pressure. She cites studies showing that yoga can reduce chronic stress, ease arthritic conditions and improve the quality of life in breast cancer patients undergoing chemotherapy.

“Yoga can make you feel better,” she said. For those who have overindulged in drink, she cautions against choosing a “hot yoga” or “Bikram yoga” class, since the room temperatures — typically 90 degrees or higher — can cause further dehydration. Instead, she recommends trying a “light” yoga routine, with particular emphasis on meditation and breathing exercises.

Susan Orem, a yoga teacher in New York City and the owner of the Heathen Hill yoga retreat in the Catskills, says that a brief 20- to 30-minute yoga sequence that includes sun salutations, along with a few good twists and restorative poses, may well bring relief. It’s important to remain “mindful” on the yoga mat, says Ms. Orem — or Lip, as she is known to all — focusing on your breathing and the poses “without projecting what’s going to happen after or regretting what you did to arrive here in this condition.”

She recommends starting with sun salutations, an energetic series of poses that “increase the heart rate, build heat in the body and get the breath flowing in a way that can improve oxygen uptake.” There are several types of sun salutations, including the variation shown in our slide show, above. Individual poses within the salutation sequence include the Upward Salute, Standing Forward Bend, Lunge and Downward-Facing Dog Pose.

The use of props like eye pillows, bolsters and blocks can be particularly helpful to anyone with a hangover, along with drinking plenty of water before and after the session. If the head is pounding, Ms. Orem recommends modifying the basic sun salutation by keeping the head raised above the heart during the poses. Raising the head “also prevents it from falling off,” she joked as she demonstrated the sequence recently at Reflections yoga studio in New York City.

If moving through a sun salutation proves too much to ask of the intrepid partygoer, these energetic moves can be skipped entirely. Instead, begin with some twists, which are gentler and done sitting on a solid floor. Two twists that Ms. Orem recommends are Bharadvaja’s Twist or a variation of Marichi’s Pose.

Twisting poses are beneficial, yoga tradition holds, for what the Indian yoga master B.K.S. Iyengar calls their “squeeze and soak” action — in effect, squeezing the organs like a wet sponge, so that they expel old blood and allow fresh, richly oxygenated blood to take its place. Twists are also said to improve digestion and increase flexibility of the spine, shoulders and hips.

Dr. Timothy McCall, a physician and the author of “Yoga as Medicine,” said that the idea that twisting poses cleanse the organs is “pure speculation” from a Western medical standpoint. Still, Dr. McCall, the medical editor of Yoga Journal magazine and a practicing yogi, says that a mindful and varied yoga practice that includes twists could be helpful in easing the symptoms of a hangover.

A few restorative poses, restful postures in which the body is typically supported by bolsters or blocks to encourage relaxation, are a great way to complete the sequence. Whereas a classic restorative sequence might involve a 10-minute headstand and 10-minute shoulder stand, “the price you are going to pay for having your head in that position may be too high” for someone with a hangover, Ms. Orem said.

As an alternative, she recommends a seated forward bend, such as Bound Angle pose, with the head supported on a block, as well as Child’s Pose, Legs Up the Wall Pose or Corpse Pose.

Jessica Handelman, who works and practices yoga at Reflections, agreed that restorative poses, including seated forward bends, helped her ease a hangover. “At least you’re on the ground,” she said.

Her colleague Sam Prestidge adds his own advice for getting past the misery: avoid inversions, or poses in which the heart is higher than the head. That rules out poses like shoulder stands, hand stands and head stands. While he says he always feels better after yoga on days when he feels hung over, he adds that getting to class is always the hardest part.

All agree that there’s no one-size-fits-all approach to yoga, because everyone is different, and what soothes an aching body for one person might not work for another.

What’s important, says Dr. McCall, is the cultivation of a personalized yoga practice “that wakes up the ability to feel what is happening” in the body. “With that greater awareness,” he said, “people have the capacity to make different choices — including not drinking so much next New Year’s Eve.”

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Human Sperm Can Cure Many Diseases

Sperm is not only human a reproduction tool. Now, it has been claimed efficacious in treating many diseases.  For instance, Diabetes 1 now can be treated with sperm that has been converted into insulin. Besides diabetes, the sperm could also treat other diseases.

Diabetes Treatment

The breakthrough was pioneered by researchers from Georgetown University Medical Centre in Washington DC, USA. When tested, this technology was a success and is expected to be applicable also in humans.

Quoted from HealthDay, the use of sperm-producing cells have advantages over transplanting pancreatic cells. Sperm-producing cells taken from the testicle itself so there is no risk of rejection as in the pancreatic cell transplant from a donor.

The breakthrough was promising, and has become word of mouth because changing the function of sperm-producing cells into insulin-producing. While talking about sperm, not only the producing cells are never used in therapy but also the sperm fluid itself.

Depression Therapy

One of them revealed in a 2002 study published in the same year in the journal Archives of Sexual Behavior. Research conducted by experts at the State University of New York is reveals the benefits of sperm to treat depression in women.

This benefit is obtained when women who are depressed have intercourse with her partner without a condom and let the ejaculation happens in Ms. V. It is believed, certain compounds in the sperm, which until now has not been identified will be absorbed into the blood vessels around the vagina and provide a calming effect.

Acne Medication

Other uses of sperm has also been applied to treat acne, although no studies prove its effectiveness. But in theory, the treatment is considered sufficient for sperm entry will contain a number of nutrients that are beneficial for skin care.

Quoted from Bestacnetreatmentstips.com, nutrient content in the sperm that can fight acne is Vitamin C. These compounds are antioxidants that can detoxify or get rid of toxins and impurities that exist on the surface of the skin.

Wrinkles Drug

In addition, the antioxidant content also ensures that the sperm free of free radicals causes dull skin and wrinkles. The content of the same could be found in anti-aging products on the market early.

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1 of 4 Overweighted Women Assumes Her body Normal

Galveston, Texas, Modern lifestyles have changed the perception of obesity, even among women who are generally more sensitive about the appearance. Research shows 1 in 4 obese women do not feel troubled by her weight.

Research conducted at the University of Texas Medical Branch at Galveston is involved 2,200 adults in their productive age, between 20-39 years. More than half had a body mass index above normal.

In general, it found that 30 percent of overweighted adults feel her weight was normal. About 70 percent of obese people consider themselves just overweight, while 39 percent of obese people just take it as seriously overweight.

A scientist who led the study, Mahbubur Rahman assume the cause is a change in norms and modern lifestyle. At the present time, having a body fat has been regarded as normal and nothing to worry.

“Wherever we can find people who are overweight but overweight reasonably assume that happened,” said Rahman as quoted from HealthDay, Tuesday (23/11/2010).

This trend applies also to women, who are generally very concerned about shape and weight. Revealed in this study, only a few women who feel overweighted.

Among the overweighted female respondents, 23 percent of them think their weight is lower than the real thing. Only about 16 percent of respondents with normal weight women consider themselves too fat.

Besides disturbing appearance, being overweighted is also a risk factor for many serious diseases such as diabetes and various heart problems and blood vessels. Obesity which only occurs in the abdominal or central obesity is more dangerous than obesity are evenly distributed throughout the body.

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Fat at Your Waist is Drug for Heart Disease

The risk of heart disease generally increases when a person waistlines is getting wider. Well, this assumption may not be valid anymore, since the scientists now actually utilize fat at the waist to cure heart disease.

Scientists from Erasmus University, Notterdam, Netherlands succeeded in developing stem cells derived from fat deposits around the waist. The cell was then injected into the heart to overcome muscle damage that lead to heart failure .

Compared with stem cells derived from other organs, stem cells from fat waist is claimed to provide a number of benefits for the heart. In addition to not affect normal blood flow, the cells were also able to improve the ability of the heart in pumping blood.

In the trial against 11 men and 3 women with heart defects, the breakthrough was able to show satisfactory results. One is improving the quality of the heart muscle by 3.5 percent within 6 months after the injection of stem cells.

Improving the quality of the heart muscle was indicated from the rate of heart muscle damage was reduced by 16.2 percent. Meanwhile, the ability of the organ to pump blood increased by 5.7 percent.

Another advantage is that almost all adults now have fat around their waist, so it is not difficult to get it. Approximately from about 250 cubic centimeters of fat in the area, scientists can get at least 20 million stem cells to be injected into the heart.

“Tests prove the beginning of stem cells from fat, waist safe to use after an acute heart attack,” said one scientist involved in the trial, Dr. Eric Duckers, as quoted from Dailymail.

Trials with a larger scale will be done in the near future by involving 375 people from all over Europe. Participants involved in this research have reduced 45 percent an of their average heart blood pumping ability.

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Cigarettes, Double Stroke Risk In Women

Smoking young women run the risk of hit by stroke two-times higher compared than women who never smoke, while the heaviest smokers among them having nine times greater risk, according to a a research conducted in US, a study estimates the risk of stroke among women aged 15 to 49 years who smoke cigarettes. Current smokers 2.6 times more likely to have a stroke compared to women who never smoked.

Women who smoke the most face the highest risk, according to the study, published in the journal of the American Heart Association, Stroke, published last week.

Women who smoke 21 to 39 cigarettes per day, for example, face the risk of stroke 4.3 times higher than non-smokers, while those who smoke at least two packs of cigarettes per day face the risk of stroke 9.1 times more higher than women who never smoke.

Tobacco has long been known to increase risk of stroke, and other health hazards such as lung offices or other types of cancer, lung disease and heart disease.

However, Cole said there was not much known how the risk of stroke is influenced by the number of cigarettes smoked by someone.

Stroke usually affects older people compared with those in the study but research shows that, even in young women though, the risk of stroke increased sharply.

The researchers tracked 466 women in the United States, which already had a stroke and 604 women who never had a stroke and has a tribe, race and age.  As many as one-fifth of U.S. women aged 18 to 24 years were smokers.

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